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This interaction could be due to the mechanism of action of the drugs (i.e. a pharmacodynamic interaction), or due to one drug (the precipitant drug) impacting the other drug’s (the object drug) absorption, distribution, metabolism or excretion (a pharmacokinetic interaction). Either type of interaction (pharmacodynamic or pharmacokinetic) could result in serious adverse effects, toxicity, or in some cases, therapeutic failure. Students will submit a paper describing the mechanism of action of each drug, the underlying pharmacological/biomedical basis of the drug interaction, the clinical relevance or consequence of the interaction, and at least one recommendation to minimize or avoid the interaction if a patient was prescribed those medications (e.g. dose adjustment in one or both drugs, replace one drug with another (appropriate) drug that does not interact, etc.). Students must provide at least 4 references. Drugs = Diltiazem + cyclosporine

Date Posted: 05/03/2020
Category: Science
Due Date: 06/03/2020
Instruction
This interaction could be due to the mechanism of action of the drugs (i.e. a pharmacodynamic interaction), or due to one drug (the precipitant drug) impacting the other drug’s (the object drug) absorption, distribution, metabolism or excretion (a pharmacokinetic interaction). Either type of interaction (pharmacodynamic or pharmacokinetic) could result in serious adverse effects, toxicity, or in some cases, therapeutic failure. Students will submit a paper describing the mechanism of action of each drug, the underlying pharmacological/biomedical basis of the drug interaction, the clinical relevance or consequence of the interaction, and at least one recommendation to minimize or avoid the interaction if a patient was prescribed those medications (e.g. dose adjustment in one or both drugs, replace one drug with another (appropriate) drug that does not interact, etc.). Students must provide at least 4 references. Describe the mechanism of action and pharmacokinetic profile of each drug in the assigned drug pair. Explain the basis of the interaction, describing in detail how one drug interacts with and impacts the other. For example, if one drug impacts the metabolism of the other, which metabolizing enzyme is involved? Explain the clinical consequence(s) of the interaction, including adverse or toxic effects, therapeutic failure, or some other clinically relevant outcome, and why these consequences occur. Provide at least one appropriate recommendation to minimize or avoid the interaction. For example, if the interaction involved an antibiotic and the antibiotic should be changed, which antibiotic would be appropriate? Convey information using appropriate terminology, spelling, grammar and narrative. Use basic drug information skills, including information retrieval and citation. Click here for AMA format guidelines. Use critical thinking skills to identify the cause of a problem and provide a rational solution.
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  • Just to verify, what all do I need you to do for this paper and what are the drugs for my paper?
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  • Hello there, have you ever done a science paper before?
    User_17280 | Mar 06, 2020, 00:28 AM
  • Yes
    COMMITEDTUTOR | Mar 06, 2020, 00:59 AM
  • Just to be clear, what is it that I need from my paper and what drugs am I researching?
    User_17280 | Mar 06, 2020, 02:01 AM
  • Pharmacodynamic drug interaction with precipitant drug
    COMMITEDTUTOR | Mar 06, 2020, 02:03 AM
  • What drugs am I researching in conjunction?
    User_17280 | Mar 06, 2020, 02:09 AM
  • Diltiazem and cycrosporine
    COMMITEDTUTOR | Mar 06, 2020, 03:17 AM
  • I am in pharmacy school, so I can read the paper and know if you did something wrong, so please don’t do something wrong or plagiarize please.
    User_17280 | Mar 06, 2020, 06:02 AM
  • I am good. Actually I am currently handling pharmacology class and advanced clinical class for another student. Though it is ending this Sunday
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  • I will go with you
    User_17280 | Mar 06, 2020, 06:10 AM
  • Great. Let me work on it.
    COMMITEDTUTOR | Mar 06, 2020, 06:17 AM
  • I attached some more information
    User_17280 | Mar 06, 2020, 06:18 AM
  • When do you think you will have it done?
    User_17280 | Mar 06, 2020, 06:24 AM
  • Thank you man. Thank you so much for assigning me. I appreciate it
    COMMITEDTUTOR | Mar 06, 2020, 06:24 AM
  • In the next 12 hours I will be done
    COMMITEDTUTOR | Mar 06, 2020, 06:28 AM
  • It’s AMA format
    User_17280 | Mar 06, 2020, 06:47 AM
  • Okay. Am used to APA but I will still do it in AMA
    COMMITEDTUTOR | Mar 06, 2020, 06:49 AM
  • Any updates?
    User_17280 | Mar 06, 2020, 19:12 PM
  • hello, yes. Just few minutes like 20 minutes.
    COMMITEDTUTOR | Mar 06, 2020, 19:29 PM
  • Hello, I have uploaded the work and plagiarism report. Please go through it and get back to me. Once satisified, please remember to release the payment. Thanks so much
    COMMITEDTUTOR | Mar 06, 2020, 22:21 PM
  • aaa
    User_17280 | Mar 07, 2020, 00:29 AM
  • you there, i need some changes
    User_17280 | Mar 07, 2020, 00:29 AM
  • 1) can you add in-text citations 2) can you talk about the bad side effects when the drugs Diltiazem and Cyclosporine are combined 3) can you talk about what happens to patients when CsA levels are high 4) can you see what drugs you can use to create no drug to drug interaction. Like use the drug classes of the drugs to find another drug in the same drug class that will create no interactions
    User_17280 | Mar 07, 2020, 00:35 AM
  • You there?
    User_17280 | Mar 07, 2020, 03:13 AM
  • it is due in a hour
    User_17280 | Mar 07, 2020, 03:14 AM
  • Hello, ooh, sorry was asleep?
    COMMITEDTUTOR | Mar 07, 2020, 04:13 AM
  • Still need these changes?
    COMMITEDTUTOR | Mar 07, 2020, 04:13 AM
  • yes, not number 1 though, you did the in-text citation
    User_17280 | Mar 07, 2020, 04:14 AM
  • Can you do it in 30 minutes?
    User_17280 | Mar 07, 2020, 04:15 AM
  • Or an hour?
    User_17280 | Mar 07, 2020, 04:16 AM
  • Describe the mechanism of action and pharmacokinetic profile of each drug in the assigned drug pair. Explain the basis of the interaction, describing in detail how one drug interacts with and impacts the other. For example, if one drug impacts the metabolism of the other, which metabolizing enzyme is involved? Explain the clinical consequence(s) of the interaction, including adverse or toxic effects, therapeutic failure, or some other clinically relevant outcome, and why these consequences occur. Provide at least one appropriate recommendation to minimize or avoid the interaction.
    COMMITEDTUTOR | Mar 07, 2020, 04:18 AM
  • I believe those were the questions the paper asked. And I addressed them
    COMMITEDTUTOR | Mar 07, 2020, 04:18 AM
  • But let me check if can add what you want
    COMMITEDTUTOR | Mar 07, 2020, 04:20 AM
  • Yes, but it needs a little more detail, and another way to avoid/minimize the interaction.
    User_17280 | Mar 07, 2020, 04:20 AM
  • you there?
    User_17280 | Mar 07, 2020, 04:36 AM
  • yes
    COMMITEDTUTOR | Mar 07, 2020, 04:37 AM
  • when do you think your going to be finished with the edits?
    User_17280 | Mar 07, 2020, 04:39 AM
  • Okay. AM on it now. Could an hour be okay?
    COMMITEDTUTOR | Mar 07, 2020, 04:41 AM
  • it would have to be an hour MAX
    User_17280 | Mar 07, 2020, 04:42 AM
  • Please make sure it has an AMA formated title page
    User_17280 | Mar 07, 2020, 04:44 AM
  • you there? paper is due in 15 minutes
    User_17280 | Mar 07, 2020, 05:39 AM
  • hello are you there?
    COMMITEDTUTOR | Mar 07, 2020, 05:43 AM
  • yes, i need the paper now
    User_17280 | Mar 07, 2020, 05:44 AM
  • the last part (can you see what drugs you can use to create no drug to drug interaction. Like use the drug classes of the drugs to find another drug in the same drug class that will create no interactions) this drug interacts with almost everything. and the side effects is very hard to do away with them. The prime thing that a doctor should aim is to find the combination that will lead to the best results
    COMMITEDTUTOR | Mar 07, 2020, 05:46 AM
  • I NEED THE PAPER
    User_17280 | Mar 07, 2020, 05:46 AM
  • JUST SEND THE PAPER PLEASE
    User_17280 | Mar 07, 2020, 05:47 AM
  • So i have not added any information regarding that part. but for the part of clinical effects i have changed everything and answered what you wanted. let me upload the paper. Thanks
    COMMITEDTUTOR | Mar 07, 2020, 05:47 AM
  • PLEASE DO IT NOW
    User_17280 | Mar 07, 2020, 05:48 AM
  • HELLO
    User_17280 | Mar 07, 2020, 05:50 AM
  • PLEASE
    User_17280 | Mar 07, 2020, 05:50 AM
  • SEND THE PAPER, I NEED IT NOW
    User_17280 | Mar 07, 2020, 05:51 AM
  • Sent. Thanks
    COMMITEDTUTOR | Mar 07, 2020, 05:53 AM
  • okay use the last one. It has a cover page
    COMMITEDTUTOR | Mar 07, 2020, 05:56 AM
  • How can I contact you to work with you again?
    User_17280 | Mar 07, 2020, 06:10 AM
  • Okay, you can contact me just through this chat, just here anytime you need my help
    COMMITEDTUTOR | Mar 07, 2020, 06:12 AM
  • Okay, i will try. i am about to release the funds
    User_17280 | Mar 07, 2020, 06:15 AM
  • Thank you so much for releasing the payment. And I really appreciate working with you
    COMMITEDTUTOR | Mar 07, 2020, 06:21 AM
  • Hello, are you there?
    User_17280 | Mar 22, 2020, 16:13 PM
  • My teacher made some comments on my paper. The comments are below. More pharmacokinetic background for diltiazem (How is it metabolized, what enzymes does it inhibit. put in first section). Cyclosporine: How it is metabolized and how it is a substrate for PGP. Bases of interaction looks plagiarized (too specific. Doesn't know what metabolite 17 and 18 are). Focus on if you gave Diltiazem what would happen to plasma cyclosporine level. Underlying bases of the drug interaction and why we need to be worried about giving the two drugs together. Cite better articles, don't use Japanese Journal of ophthalmology. List the same reference one. Specify nature of interaction. What would be my recommendations to a patient if I was a pharmacist and I saw they were prescribed those two drugs
    User_17280 | Mar 22, 2020, 16:13 PM
  • Would you be able to make these changes? The paper is officially due tomorrow. I will add a tip/bonus to your payment
    User_17280 | Mar 22, 2020, 16:14 PM
  • Hello, yes am here.
    COMMITEDTUTOR | Mar 22, 2020, 16:18 PM
  • Seems some of information is new. I mean they were not included in the unitial instructions
    COMMITEDTUTOR | Mar 22, 2020, 16:21 PM
  • But anyway let me check it
    COMMITEDTUTOR | Mar 22, 2020, 16:28 PM
  • Any updates? It’s due in About 15 hours
    User_17280 | Mar 22, 2020, 19:51 PM
  • You there?
    User_17280 | Mar 23, 2020, 01:16 AM
  • hello, yeah am here.
    COMMITEDTUTOR | Mar 23, 2020, 03:40 AM
  • Any updates? its due in in 4 hours
    User_17280 | Mar 23, 2020, 04:30 AM
  • Hello
    User_17280 | Mar 23, 2020, 05:50 AM
  • Okay, please check then get back to me
    COMMITEDTUTOR | Mar 23, 2020, 06:47 AM
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  • Hello there, have you ever done a science paper before?
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  • Have you ever done a pharmacy paper before?
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  • I am much pretty familiar with this and I can handle it with a lot of professional because it is my field of specialization, please let me know if I can help you. Thank you
    Javawriter | Mar 05, 2020, 23:19 PM
  • can i help you?
    Javawriter | Mar 05, 2020, 23:20 PM
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royvance 6 years, 6 months ago
Rated 9.46 earned 23513.53 around 727 assignments.
hi, i am a science major. I guarantee you an A+ paper. Original and high quality. Kindly accept my bid
$15.00
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tutor4you 6 years, 6 months ago
Rated 9.71 earned 40687.23 around 1363 assignments.
Hello friend,Consider me because My competency lies in my ability, am a proficient tutor and i have all relevant academic resources and knowledge particularly in this field of study, i promise perfect and quality work on time,, assign it to me,, i commit my self to adhere to projects until they are finished and well-reviewed. Quality Assurance plays a major role here by making sure that all needs and requirements are well followed for the purpose of delivering quality paperwork
$16.00
  • Hello friend,Quality and originality is always my focus in any project. A plagiarism and grammatical errors free project and assignment is what my client gets.kindly Assign
    tutor4you | Mar 05, 2020, 23:20 PM
  • Hello friend,Consider me because My competency lies in my ability, am a proficient tutor and i have all relevant academic resources and knowledge particularly in this field of study, i promise perfect and quality work on time,, assign it to me,, i commit my self to adhere to projects until they are finished and well-reviewed. Quality Assurance plays a major role here by making sure that all needs and requirements are well followed for the purpose of delivering quality paperwork
    tutor4you | Mar 05, 2020, 23:20 PM
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kennwals 6 years, 6 months ago
Rated 9.62 earned 40189.97 around 1191 assignments.
Dear customer, I am a scholar and writer from the United States with over 10 years experience in writing academic papers. I have a keen attention to details, high regard for top quality, zero room for plagiarism and a strict allegiance to set deadlines. My mastery in referencing and citations is unparalleled. Kindly accept my bid so that I can begin working on the assignment for you. I am looking forward to work with you.
$45.00
  • Have you ever done a pharmacy paper before?
    User_17280 | Mar 06, 2020, 02:31 AM
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harvardtutor 6 years, 6 months ago
Rated 8.93 earned 38096.91 around 1156 assignments.
Hi, I will ensure the delivery of a high paper within given deadline. I have worked on similar papers in the past and I can assure you of an A grade paper.
$30.00
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masheti 6 years, 6 months ago
Rated 9.29 earned 13455.44 around 465 assignments.
Being the best tutor, I assure you the best. Your assignment will be free from plagiarism and also uploaded before time. Kindly accept me. Thank you.
$15.00
  • Have you ever done a pharmacy paper before?
    User_17280 | Mar 06, 2020, 02:31 AM
  • yes
    masheti | Mar 06, 2020, 03:21 AM
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Excellentessays 6 years, 6 months ago
Rated 9.72 earned 56371.38 around 2080 assignments.
Hello dear, I'm a professional and masters graduate writer with over 8 years tutor Experience. I guarantee Grade A+++ Quality papers, strictly follow instructions and no plagiarism at all as well as no grammatical errors and timely submissions. Many Thanks
$15.00
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bryan 6 years, 6 months ago
Rated 8.54 earned 8526.70 around 280 assignments.
Hello dear, I'm a professional and masters graduate writer with over 8 years tutor Experience. I guarantee Grade A+++ Quality papers, strictly follow instructions and no plagiarism at all as well as no grammatical errors and timely submissions. Many Thanks
$15.00
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kingz 6 years, 6 months ago
Rated 9.4 earned 52183.12 around 1434 assignments.
Hello, please assign this to me and be assured of quality work which will be delivered in time. I promise you 100% satisfactory work. Thank you in advance
$15.00
  • Hello there, have you ever done a science paper before?
    User_17280 | Mar 06, 2020, 00:28 AM
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funwriter 6 years, 6 months ago
Rated 9.44 earned 21955.32 around 740 assignments.
Hey, I will be pleased to offer quality work on time and free from plagiarism. Kinldy assign me this work and I promise to deliver high quality well researched work that will guarantee you good grade. Thank you
$25.00
  • Have you ever done a pharmacy paper before?
    User_17280 | Mar 06, 2020, 02:28 AM
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academicminded 6 years, 6 months ago
Rated 9.5 earned 87858.79 around 3236 assignments.
Hello, kindly select my bid. I am an expert in your topic of concern. Be sure I will deliver high quality work that meets your expectations, professional standards and timely submission. Thank you.
$30.00
  • You ever done a science paper before
    User_17280 | Mar 06, 2020, 02:26 AM
  • Yes
    academicminded | Mar 06, 2020, 02:28 AM
  • Just to verify, what all do I need you to do for this paper and what are the drugs for my paper?
    User_17280 | Mar 06, 2020, 02:32 AM
  • Okey. Will you assign me if I tell you everything?
    academicminded | Mar 06, 2020, 02:34 AM
  • Or you will assign other tutor?
    academicminded | Mar 06, 2020, 02:34 AM
  • It depends on your answere
    User_17280 | Mar 06, 2020, 02:38 AM
  • Answers
    User_17280 | Mar 06, 2020, 02:38 AM
  • If you really need my help assign me friend
    academicminded | Mar 06, 2020, 02:41 AM
  • If you doubt me choose another tutor to help you dear. Thank you
    academicminded | Mar 06, 2020, 02:43 AM
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TalentedTeacher 6 years, 6 months ago
Rated 9.33 earned 18202.75 around 525 assignments.
Please assign your work and I promise quality work as usual. I will be waiting friend
$35.00
  • I have read the instructions and I can promise to meet the requirements of your project and I too guarantee good paper and deliver in time before deadline.
    TalentedTeacher | Mar 06, 2020, 05:16 AM
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