Instruction
Topic #1: List and explain the four most important factors that control the relative reactivity of a carbonyl-containing functional group in an addition or substitution reaction.
Topic #2: Arrange the following in order of decreasing reactivity to nucleophilic acyl substitution:
ester, amide, acid anhydride.
Explain your logic. You should include :
1) the order in decreasing reactivity
2) Discussion of these factors as they pertain to the above compounds: carbonyl carbon delta +, resonance, steric effects, and leaving group