Instruction
Description: Aspirin was one of the first drugs to ever be produced. In the late 1890s Aspirin was discovered by Felix Hoffman at Bayer in Germany. It wasn’t till much later that we discovered the mechanism by which Aspirin works. Today, there is a huge wealth of information available about how exactly Aspirin inhibitors Cyclo Monooxygenase (COX). For this worksheet, your job is to investigate how Aspirin works on both a pathway level and a mechanistic level.
Part 1: Instructions: For this, your job is to investigate how Aspirin works on both a pathway level and a mechanistic level. For this presentation, walk the audience through the pathway (structures, metabolite names, enzymes, cofactors) that Aspirin inhibits. As well, draw out the mechanism by which Aspirin covalently inhibits COX.
Part 2: Instructions: Aspirin inhibits prostaglandins from being formed. Explain what prostaglandins do in respect to inflammation and how inhibiting their formation would reduce inflammation.
What to submit: Submit the pathways and mechanism by PDF or Image. Submit the Prostaglandins summary as a word document or PDF