Protein Function Introduction: Hemoglobin is an essential protein necessary for the transport of oxygen in the body. Biochemists study the molecular activities necessary for the exchange and transport of oxygen between the body cells and lungs. You should compile your work for this task in a single document (e.g., Microsoft Word, Google Document) that includes diagrams, models, text explanations, and references. If a requirement asks for an explanation, you should provide a written response in a narrative style (i.e., complete sentences rather than bullet points). Note: Multimedia presentations (e.g., PowerPoint, Keynote) will not be accepted due to potential originality concerns. Note: Please save submission documents as *.doc, *.docx, *.rtf, or *.pdf files. If you are using Google Documents, you must save the file in *.pdf format and upload the *.pdf file. Requirements: A. Create an original model of hemoglobin, with clear labels, that shows how oxygen is carried by the molecule. Note: The inclusion of the following components aids in showing how oxygen is carried: subunits, heme groups, iron atoms, and oxygen molecules. Note: Take a picture or screenshot of your completed model as evidence that you created it. You can include the picture or screenshot as part of your document, or you can submit it in Taskstream as a separate attachment. 1. Explain two differences between the oxygenated and deoxygenated states of hemoglobin. 2. Explain how pH impacts the binding and release of oxygen by hemoglobin. a. Create an original graph that demonstrates the relationship between hemoglobins oxygen binding and oxygen concentration at different pH levels. 3. Create an original diagram, or series of diagrams, with clear labels, that compares the biochemical (protein) structure of hemoglobin to myoglobin. Note: The inclusion of the following components aids in showing the comparison: subunits, heme groups, and iron atoms. Note: Take a picture or screenshot of your completed diagram as evidence that you created it. You can include the picture or screenshot as part of your document, or you can submit it in Taskstream as a separate attachment. B. Demonstrate your understanding of sickle cell anemia by doing the following: 1. Create an original diagram that demonstrates the amino acid difference between normal and sickle forms of hemoglobin. Note: Take a picture or screenshot of your completed diagram. You can include the picture or screenshot as part of your document, or you can submit it in Taskstream as a separate attachment. 2. Create an original diagram that demonstrates the difference between normal and sickle red blood cells at the cellular level. Note: Take a picture or screenshot of your completed diagram. You can include the picture or screenshot as part of your document, or you can submit it in Taskstream as a separate attachment. 3. Explain how diseased cells differ from normal red blood cells in their capacity to transport oxygen. 4. Explain the molecular inheritance of sickle cell anemia by doing the following: a. Identify the type of inheritance seen in sickle cell anemia. b. Create an original diagram (e.g., pedigree charts, Punnett squares), or series of simple diagrams, that demonstrates how sickle cell genes are inherited. Note: Take a picture or screenshot of your completed diagram. You can include the picture or screenshot as part of your document, or you can submit it in Taskstream as a separate attachment. C. When you use sources, include all in-text citations and references in APA format. Note: For definitions of terms commonly used in the rubric, see the attached Rubric Terms. Note: When using sources to support ideas and elements in an assessment, the submission MUST include APA formatted in-text citations with a corresponding reference list for any direct quotes or paraphrasing. It is not necessary to list sources that were consulted if they have not been quoted or paraphrased in the text of the assessment.

Protein Function Introduction: Hemoglobin is an essential protein necessary for the transport of oxygen in the body. Biochemists study the molecular activities necessary for the exchange and transport of oxygen between the body cells and lungs. You should compile your work for this task in a single document (e.g., Microsoft Word, Google Document) that includes diagrams, models, text explanations, and references. If a requirement asks for an explanation, you should provide a written response in a narrative style (i.e., complete sentences rather than bullet points). Note: Multimedia presentations (e.g., PowerPoint, Keynote) will not be accepted due to potential originality concerns. Note: Please save submission documents as *.doc, *.docx, *.rtf, or *.pdf files. If you are using Google Documents, you must save the file in *.pdf format and upload the *.pdf file. Requirements: A. Create an original model of hemoglobin, with clear labels, that shows how oxygen is carried by the molecule. Note: The inclusion of the following components aids in showing how oxygen is carried: subunits, heme groups, iron atoms, and oxygen molecules. Note: Take a picture or screenshot of your completed model as evidence that you created it. You can include the picture or screenshot as part of your document, or you can submit it in Taskstream as a separate attachment. 1. Explain two differences between the oxygenated and deoxygenated states of hemoglobin. 2. Explain how pH impacts the binding and release of oxygen by hemoglobin. a. Create an original graph that demonstrates the relationship between hemoglobins oxygen binding and oxygen concentration at different pH levels. 3. Create an original diagram, or series of diagrams, with clear labels, that compares the biochemical (protein) structure of hemoglobin to myoglobin. Note: The inclusion of the following components aids in showing the comparison: subunits, heme groups, and iron atoms. Note: Take a picture or screenshot of your completed diagram as evidence that you created it. You can include the picture or screenshot as part of your document, or you can submit it in Taskstream as a separate attachment. B. Demonstrate your understanding of sickle cell anemia by doing the following: 1. Create an original diagram that demonstrates the amino acid difference between normal and sickle forms of hemoglobin. Note: Take a picture or screenshot of your completed diagram. You can include the picture or screenshot as part of your document, or you can submit it in Taskstream as a separate attachment. 2. Create an original diagram that demonstrates the difference between normal and sickle red blood cells at the cellular level. Note: Take a picture or screenshot of your completed diagram. You can include the picture or screenshot as part of your document, or you can submit it in Taskstream as a separate attachment. 3. Explain how diseased cells differ from normal red blood cells in their capacity to transport oxygen. 4. Explain the molecular inheritance of sickle cell anemia by doing the following: a. Identify the type of inheritance seen in sickle cell anemia. b. Create an original diagram (e.g., pedigree charts, Punnett squares), or series of simple diagrams, that demonstrates how sickle cell genes are inherited. Note: Take a picture or screenshot of your completed diagram. You can include the picture or screenshot as part of your document, or you can submit it in Taskstream as a separate attachment. C. When you use sources, include all in-text citations and references in APA format. Note: For definitions of terms commonly used in the rubric, see the attached Rubric Terms. Note: When using sources to support ideas and elements in an assessment, the submission MUST include APA formatted in-text citations with a corresponding reference list for any direct quotes or paraphrasing. It is not necessary to list sources that were consulted if they have not been quoted or paraphrased in the text of the assessment.

User_7317 added on 06/28/15 at 03:31 AM (PST):

Not exactly what my professors want, they want each question answered, not in an essay form. And they also want "original" diagram of an hemoglobin, it cant be a picture copied and pasted.

User_7317 added on 06/29/15 at 09:26 AM (PST):

Senior, the pictures are supposed to be originals, not copied. They are to be drawn and a picture of them taken, then uploaded. Thanks